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推廣活動
風濕免疫疾病的分子遺傳學
推薦老師：分醫所余家利老師

　　 醫學是生物學的一個應用分支，也是維護人類健康的重要學門之一。剖視醫學的研究趨勢由最先的症候學、器官組織的病態生理學，逐次進步為細胞的病態機轉，近代的醫學研究實已經進入了次細胞學及分子生物學的層次。號稱自達爾文進化論以來，最浩大的生物探索工程「人類基因體的十億個鹼基的解碼工作」，已於公元2000年一月完成。自此，一連串的新鮮生物醫學名詞陸續被刻意創造出來，但分子生物醫學的研究一日千里是無可爭辯的。
而風濕免疫疾病則是人類慢性疾病中的「難病」，是一種由基因、內分泌、神經、環境及免疫調控異常等諸多因素所交織而成的慢性難治性疾病。風濕免疫疾病相關的基因非常複雜，包括染色體1、2、4、6、7及6…，但是均止於「相關性」而非「致病性」基因，具有自體免疫的遺傳背景再加上環境因素的刺激皆有可能會誘發出風濕免疫疾病。「調整體質來增強抵抗力或治療疾病」是人類自古以來的夢想，這個夢想應該可以從認識風濕免疫疾病的分子遺傳學開始。
祝福有緣來參觀此區圖書展示的朋友們，會有高於預期的收獲。

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編號 書名 / 作者 出版社 出版年 索書號 適用等級 摘要
1 Antigen processing and presentation protocols / edited by Joyce C. Solheim Humana Press 2001 QW525 A629 2001 Advanced bookpic Book Description Well-recognized and innovative experimentalists detail their cutting-edge methods for studying the antigen processing and presentation. Drawing on expertise from biochemistry, cell biology, and immunology, they describe step-by-step methods designed to question how MHC-binding peptides are generated, to test how peptides are delivered to MHC molecules, to analyze MHC peptide-binding patterns, and to assay the T-cell response to the MHC/peptide complex. Emphasis is given those technical steps critical for experimental success that are often omitted from methods published in the primary literature. Eminently accessible and state-of-the-art, Antigen Processing and Presentation Protocols provides both new and experienced investigators with highly practical tools that will extend the questions that can be asked, and effectively be answered, concerning antigen processing/presentation. Booknews Medical specialists from around the world present step-by-step methods for studying the processing of antigens by major histocompatibility complex (MHC). Some of the methods they describe include ways to examine how MHC-binding peptides are generated, to test how peptides are delivered to MHC molecules, to analyze MHC peptide-binding patterns, and to gauge the T-cell response to the MHC/peptide complex. Each chapter offers readily reproducible experiments and suggestions for how to avoid pitfalls and failure.
2 Apoptosis and autoimmunity / edited by M. Hermann and J.R. Kalden Wiley-VCH 2003 QH671 A6528 2003 Advanced bookpic From the Publisher This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.
3 CD4+CD25+ regulatory T cells : origin, function and therapeutic potential / B. Kyewski and E. Suri-Payer (eds.) Springer 2005 W1  C936m v.293  2005 Advanced bookpic From the Publisher The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the sucessful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival.
4 Current concepts in autoimmunity and chronic inflammation / A. Radbruch and P.E. Lipsky (eds.) Springer 2006 W1  C936m v.305  2006 Basic bookpic About this book The ethiopathologies of autoimmune diseases are complex. A broad variety of cell types and gene products are involved. However, clinical and experimental evidence suggests that the importance of an individual factor changes during the course of the disease. Factors and cell types that induce acute autoreactivity and initiate an autoimmune disease could be distinct from those that drive a chronic course of that disease. Written for： Researchers and scientists in the field of autoimmune diseases. Keywords： B cell tolerance、CD25+CD4 Treg、SLE、apoptosis、autoimmune disease、autoinflammatory syndromes、blood-brain barrier、cytokines、multiple sclerosis、necrosis、rheumatic arthritis、self-tolerance.
5 Harrison's rheumatology / editor, Anthony S. Fauci ; associate editor, Carol A. Langford McGraw-Hill 2006 WE544 H323 2006 Basic bookpic Doody's Reviews **Reviewer：Tammy P Cheng, MD(Barnes-Jewish Hospital) **Description：Harrison's Rheumatology provides a worthy reference in the field of rheumatology with individual chapters written by leading experts in clinical rheumatology. This book provides a fairly comprehensive overview of rheumatological disorders. **Purpose：The purpose of Harrison's Rheumatology is to provide an updated introduction to clinical immunology and rheumatology. This book provides an important contribution to the field of internal medicine and rheumatology. **Audience：Primarily written for trainees in rheumatology, as well as practitioners seeking an updated introduction on rheumatology, this book provides authoritative information on relevant immunological principles and the diagnoses of rheumatic diseases. **Features：Harrison's Rheumatology covers a wide variety of connective tissue disorders cared for by rheumatologists. The information is concise yet thorough enough for a well-rounded introduction to rheumatology. This book provides excellent color illustrations and concise basic-science pathogenic mechanisms. Compared to other noted works for introductory rheumatology such as Primers in Rheumatic Diseases or Current Diagnosis and Treatment in Rheumatology, Harrison's Rheumatology fills a needed gap for a concise and well-referenced overview of rheumatology. One minor drawback is that this book does not delve into the details of therapeutic management. **Assessment：I think that this book is a very worthy contribution to the field of rheumatology. The authors did a very nice job of discussing the various differentials to be considered in the diagnoses of rheumatic disorders. This provides a helpful reference for clinicians in general internal medicine, as well as trainees rotating through rheumatology.
6 Immunobiology of natural killer cell receptors / E. Vivier and M. Colonna (eds.) Springer 2006 W1  C936m v.298  2006 Advanced bookpic Book Description Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.
7 Immunoendocrinology in health and disease / edited by Vincent Geenen and George Chrousos Marcel Dekker 2004 WD305 I325  2004 Basic bookpic Synopsis One of the first comprehensive references dealing specifically with this new field of research, this text offers a full scientific picture of where the immune and neuroendocrine systems intersect. The author places our current understanding of system components, mechanisms, and functions side by side with clinical results to illustrate the many ramifications of their interaction in human health and disease management. He shows the significance of immunoendocrinology in the pathogenesis and treatment of autoimmune, endocrine, infectious, allergic, inflammatory, infectious, and neoplastic diseases, providing novel insights on Type 1 diabetes, rheumatoid arthritis, HIV, and a range of other clinical disorders. Gathering together the latest research on the study of the immune system and its related functions, this text looks at the scientific and clinical aspects, as well as the mechanisms of disease.
8 Immunogenetics of autoimmune disease / Jorge Oksenberg, David Brassat [editors] Landes Bioscience/Eurekah.com 2006 WD305 O41i  2006 Advanced bookpic Book Description Written by top experts in the field, Immunogenetics of Autoimmune Disease summarizes the latest knowledge in the field of immunogenetics covering a variety of topics relating to autoimmune diseases. The book summarizes the latest knowledge in a friendly presentation based on a disease by disease approach. This will perfectly fit for a bench to bedside approach. Table of Contents 1. HLA and Autoimmunity: Structural Basis of Immune Recognition. 2. Genomic Variation and Autoimmune Disease. 3. Endocrine Diseases: Type I Diabetes Mellitus. 4. Endocrine Diseases: Graves' and Hashimoto's Diseases. 5. Central and Peripheral Nervous System Diseases. 6. Immunogenetics of Rheumatoid Arthritis, Systemic Sclerosis. 7. Gastroenterologic and Hepatic Diseases. 8. Inflammatory Myopathies: Dermatomyositis, Polymyositis. 9. Hematologic Diseases: Autoimmune Hemolytic Anemia. 10. Genetics of Autoimmune Myocarditis.
9 Immunogenicity of therapeutic biological products : National Institutes of Health, Bethesda, MD, USA, Oct. 31st-Nov. 2nd, 2001 / volume editors, Fred Brown, Anthony Mire-Sluis Karger 2003 QW541 I335  2003 Advanced bookpic Synopsis Immune responses to biological products have occurred with many approved therapeutics. The proportion of patients mounting an immune response is product dependent and the clinical significance of the immune response also varies with the nature of the product. Some products can induce production of significant levels of antibodies without any detectable effect on the activity of the product. However, neutralizing antibodies can attenuate the efficacy of the treatment and significant adverse clinical events can be seen if neutralizing antibodies cross-react with patients’ endogenous proteins. Prediction of immunogenicity includes the use of bio-informatics to predict T-cell epitopes, T-cell stimulation assays and in vivo transgenic animal models. Approaches to prevent immunogenicity involve methods to design out immunogenic sequences, protein pegylation and inducing tolerance. Current methods for assessing and detecting immunogenicity include in vivo animal models, antibody assays and biological assays. The advantages and disadvantages of the various methods illustrate that a battery of tests is required to appropriately monitor patients’ immune responses during clinical trials.
10 Immunogenomics and human disease / [edited by] András Falus John Wiley 2006 QW541 I332 2006 Advanced bookpic From the Publisher / Synopsis This book provides an overview of key conceptual and molecular technologies being deployed in immunogenomics, followed by detailed evaluations of the impact of genomics and systems biology on important areas such as cancer immunology, autoimmunity, allergy and the response to infection. Synopsis Contrasted to hypothesis-driven immunological research, immunogenomics is here described as a more interactive and flexible relationship between classical research and the discovery-driven approach. Researchers in genetics, immunology, and other specialties from Hungary and elsewhere in Europe, North America, and Japan survey its use and potential in human health care. Their topics include genotyping methods and disease gene identification, the genomic and proteomic analysis of activated human monocytes, genomics and functional differences of dendritic cell subsets, and histamine genomics and metabolomics.
11 Immunology, infection, and immunity / edited by Gerald B. Pier, Jeffrey B. Lyczak, Lee M. Wetzler ASM Press 2004 QW504 I333 2004 Basic bookpic From the Publisher Ideally suited for upper-division and graduate-level biology students as well as medical and dental students with a good background in basic biology, biochemistry, genetics, and cell biology, this book will also appeal to scientists seeking to expand their knowledge of immunology. With a focus on the relatedness of immunology and microbiology, Immunology, Infection, and Immunity covers both the foundation concepts of immunology, among the most exciting in modern biology and medicine, and their application to the real world of diseases and health. This new text combines clear narratives of how the immune system functions, relying in many instances on supporting data from experiments. Examples and illustrations depict basic immunologic processes in conjunction with their role in infectious or other diseases in order to teach both basic and applied aspects of immunology. In addition to an emphasis on infectious diseases, the book focuses strongly on those areas where the immune system does not act when it should as well as areas where the overactivity or dysregulation of the immune system is a cause of pathology. To bring the full flavor and excitement of immunology to new students, the editors have assembled an outstanding group of contributors with expertise in multiple areas of immunology who provide the most up-to-date information in this quickly moving field.
12 Infection and autoimmunity / editors, Yehuda Shoenfeld, Noel R. Rose Elsevier 2004 WD305 I43  2004 Basic bookpic Book Description Autoimmune diseases are conditions where the immune system attacks the body organs instead of foreign invaders. This book deals with the various mechanisms which infectious agents can trigger autoimmunity such as molecular mimicry, polyclonal activation and others. An overview is given with regard to bacteria, viruses and parasites associated with autoimmunity. There is a summary on classical autoimmune diseases and the infecting agents that can induce them.
13 Modern immunosuppressives / edited by H.-J. Schuurman, G. Feutren, and J.-F. Bach Birkhäuser Verlag 2001 QW920 M689 2001 Advanced bookpic Synopsis Expanding from the classic use of immunosuppressants in transplantation and rejection, this current overview highlights their new roles in clinical medicine. Immunosuppressants are at the forefront of new treatment modalities. Individual chapters focus on their use not only in prevention or treatment of transplant rejection, but also on their use in immune-complex and autoimmune diseases, including rheumatoid arthritis; on combination therapies to achieve synergy in immunosuppression; on new drugs, low molecular weight chemicals, the use of antibodies and gene therapy; on immunological tolerance to prevent or inhibit transplant rejection; and how data derived from transplant studies can be applied to other avenues of immunosuppression. Clinicians and researchers will appreciate the scope of the work and the presentation of new approaches in the rapidly developing field of immunosuppression.
14 Molecular autoimmunity : in commemoration of the 100th anniversary of the first description of human autoimmune disease / edited by Moncef Zouali Springer 2005 WD305 M7184 2005 Advanced bookpic From the Publisher 2004 marks the 100th anniversary of the first description of the autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder, by Julius Donath and Karl Landsteiner. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
15 Molecular mimicry : infection inducing autoimmune disease / M.B.A. Oldstone (ed.) Springer 2005 W1  C936m v.296  2005 Advanced bookpic From the Publisher The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative for the initial definition of mimicry. At least 30 years prior to our initial description of molecular mimicry involving cross-reactions between numerous microbes, on the polyclonal antibody level, streptococcus was believed to react with renal glomeruli, heart and basal ganglia to account for the glomerulonephritis, heart and valvular disease and chorea, respectively. However, subsequent research showed that the nephritis was caused by immune complex deposits and the tissue damage they produced. Later, in 1990, the cross-reactivity of streptococcal antigen with myocardial antigens on a clonal level was uncovered. Hence, for both historical reasons and mechanistic understanding, it is best to provide evidence for cross-reactivity at the clonal level to prove that molecular mimicry exists.
16 Principles of molecular rheumatology / edited by George C. Tsokos Humana Press 2000 WE544 P9567 2000 Basic bookpic Doody Review Services Reviewer: Deborah Jane Lenschow, MD, PhD (Washington University School of Medicine) Description: The editor and contributors of this work provide a new approach to the study of rheumatology by integrating the most recent advances in biochemistry and cellular and molecular biology with the pathogenesis of the major rheumatic diseases and the therapeutics being used today. Purpose: The editor and a panel of respected clinicians and scientists provide a resource to understand the basic cellular and molecular biology that plays a role in rheumatic disease. Audience: Clinical trainees in the field of rheumatology are the intended audience. Features: In the first two sections of the book basic cellular and molecular issues such as T and B cell activation, apoptosis, viral infections, and the complement system are covered. In the third section contributors then take a unique approach to the major rheumatic disorders by integrating the basic biological mechanisms at play in these diseases. While many of the major categories of rheumatic diseases are covered, one of the few shortcomings of this textbook is that there is no discussion of two important areas: crystal induced diseases and the seronegative spondyloarthropathies. Finally, current therapeutics that are utilized for the treatment of these diseases are discussed in terms of their molecular and cellular mechanism of actions. Assessment: Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approiach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.
17 The autoimmune diseases / edited by Noel R. Rose, Ian R. Mackay Elsevier Academic Press 2006 WD305 A9395 2006 Advanced bookpic From the Publisher The Autoimmune Diseases comprehensively describes the clinical expressions of all known autoimmune diseases, as well as the experimental bases of autoimmunity and failure of tolerance. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and particular diseases of the blood, skin, eye, kidney, and liver. The 43 chapters are authored by worldwide authoritative contributors. KEY FEATURES: * provides comprehensive discussions of all autoimmune diseases and organ systems * offers "bench to bedside" coverage of autoimmunity for both clinicians and scientists * discusses the biologic basis of disease at genetic, molecular, cellular, and epidemiologic levels * examines the environmental determinants of autoimmune disease * examines the association between autoimmunity and aging, cancer, and AIDS
18 The molecular immunology of complex carbohydrates-2 / edited by Albert M. Wu Kluwer Academic/Plenum 2001 QU75 M718 2001 Advanced bookpic Synopsis This volume contains the lectures and poster materials of three meetings promoting glycobiology organized by Wu (Glyco Research Laboratory, Chang-Gung U., Taiwan) and held in Taiwan during 1999 and 2000. Forty-nine contributions cover topics in the areas of carbohydrate-protein interactions related to plant and animal lectins; structure and antigenicity of glycoconjugates; glycotopes expression, metabolism, and functions; complex carbohydrates in development and treatment of cancer; and complex carbohydrates in microbial and viral infections and vaccine design.
19 Toll-like receptors in inflammation / Luke A.J. O'Neill, Elizabeth Brint, editors Birkhäuser Verlag 2005 QW570 T651  2005 Advanced bookpic Book Description A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.