推薦老師：藥理學研究所林泰元老師
幹細胞是人體內一種相當原始、未特化的細胞，具有增生、分化成各種組織及器官細胞的潛力，來源為骨髓幹細胞、臍帶血幹細胞及胚胎幹細胞；依據其分化潛能可分為單效性（分化為一種細胞）、複效性（分化成胚胎期同源細胞）和全效性（幾乎可分化成人體中任何一種細胞）。幹細胞因具上述特性，可運用於再生醫學以修復、替代人體已缺損的組織及器官，幹細胞的應用可說是開啟了再生醫學的大門，也成為下一世代治療疾病的希望。
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| 編號 | 書名 / 作者 | 出版社 | 出版年 | 索書號 | 適用等級 | 摘要 |
|---|---|---|---|---|---|---|
| 1 | Adult stem cell standardization / editor, Paolo Di Nardo | River | 2011 | QU325 A2442 2011 | Basic |
Stem cell research and technology represent a major challenge for treating otherwise noncurable patients. A decade of intensive research has demonstrated that initial hopes based more on the will to succeed than on solid scientific bases can be translated into factual techniques only by adopting more rigorous procedures and strategies. Among other major impediments, the failure so far experienced in applying stem cell technologies to repair parenchymal organs can be ascribed to the lack of sufficient knowledge of basic mechanisms, but also to the lack of standardized criteria and protocols. Very often each laboratory follows its own "recipe" using erratic nomenclature and non-comparable, if not confusing, experimental protocols. All this makes it difficult to learn from the others and, ultimately, hampers the advance of knowledge on stem cell behavior.
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| 2 | Artificial cells : biotechnology, nanomedicine, regenerative medicine, blood substitutes, bioencapsulation, and cell/stem cell therapy / Thomas Ming Swi Chang | World Scientific | 2007 | WH450 C456a 2007 | Basic |
This is the first book that provides a comprehensive review of the entire area of artificial cells. The author, a pioneer of the field, invented the first artificial cells some 50 years ago and has continued to carry out active research in this field. Since then, there have been explosive research activities around the world on artificial cells, especially in fields related to biotechnology, nanomedicine, cell therapy, blood substitutes, drug delivery and others. However, instead of the term "artificial cells," many authors use other terminologies such as blood substitutes, bioencapsulation, liposomes, nanoparticles and so on. Furthermore, papers in this highly interdisciplinary area are published in numerous journals specializing in chemistry, medicine, surgery, bioengineering and others, while books in this area are mostly multi-authored, describing very specific and narrow areas. As a result, any meaningful literature search for a complete idea of the present status of the whole field of artificial cells is impossible.
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| 3 | Bone marrow transplantation across major genetic barriers / editors, Yair Reisner, Massimo F. Martelli | World Scientific | 2010 | WH380 B71193 2010 | Basic |
The importance of bone marrow transplantation for patients who do not have a matched sibling donor cannot be overestimated. This subject has always been in the public domain, accentuated by dramatic appeals, from time to time, to search for matched volunteer donors in the public at large. Unfortunately, the availability of such donors is limited, due to the remarkable genetic diversity of humans. Thus, although registries of such volunteers now include more than eight million individuals, we still face the problem of finding a matched donor for about 30% of patients in need. To address this burning issue, extensive clinical and basic research is performed in leading institutes around the world. This book presents updated accounts of the different aspects of this research. The scope of the book is very wide, including strategies to overcome graft vs. host (GvH) disease and graft rejection, cell therapy to prevent leukemia relapse, and a range of modalities to improve immune reconstitution after transplantation. In addition, new approaches to induce immune tolerance towards organ transplants by means of hematopoietic stem cell transplantation are extensively reviewed.
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| 4 | Cancer stem cells / edited by William L. Farrar | Cambridge University | 2010 | QZ202 C215657 2010 | Basic |
A remarkable paradigm shift has occurred in recent years regarding the biological origins of cancer. The cancer stem cell hypothesis has challenged the foundational notions of cancer, and the therapeutic implications have been profound. Compelling evidence indicates that errors in the development of a small subset of adult stem cells can lead to cancer. Only this small sub-population of cells has the inherent ability to form tumors and metastasize. This book discusses the emerging field of cancer stem cell research, with contributions from leading experts on the basic biology, genetic pathways, and potentials for therapeutic targeting of cancer stem cells. It also covers clinical challenges for these new discoveries, namely, that cancer stem cells might be resistant to conventional chemotherapeutic and radiological treatments and may be at the biological core of relapse and therapeutic resistance. This book is an essential concise guide to the latest discoveries and therapies in cancer research.
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| 5 | Cancer stem cells : methods and protocols / edited by John S. | Humana | 2009 | QZ202 C2151 2009 e-book | Basic |
Through the revolutionary concept of cancer stem cells, cancer research has been reinvigorated to study the role of these unique cells in cancer propagation and as targets of innovative therapies. In Cancer Stem Cells: Methods and Prools, preeminent researchers have compiled cancer stem cell research techniques and prools to promote healthy competition, discourse, and collaboration in this vital field. The volume covers extensive topics such as identification and isolation of cancer stem cells, animal models of cancer stem cells, methylation profiling, the contribution of the niche in the regulation of cancer stem cells, immunologic targeting, and the use of normal stem cells as a treatment, among other subjects. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory prools, and expert notes on troubleshooting and avoiding known pitfalls.
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| 6 | Cartilage repair strategies / edited by Riley J. Williams III ; with forewords by Lars Peterson and Brian J. Cole | Humana | 2007 | WE300 C3275 2007 e-book | Basic |
The focus of this book is to create a comprehensive analysis of cartilage injury and repair strategies. Twenty chapters cover proven and emerging procedures and methodologies. Readers will be able to understand the clinical problem, appropriate diagnosis, and repair strategies relevant to first line and secondary cartilage repair procedures. The purpose is to provide a comprehensive overview of the topic of cartilage restoration by authors who are experts in their field. These valuable objectives are accomplished in a collection of who's who in cartilage procedures, including William Bugbee on ostecartilage transplantation, Lars Peterson on autologous cell implantation, Hollis Potter on cartilage imaging, and many others. The editor, Riley Williams, is a highly respected leader in the field and has helped develop the cartilage repair institute and advanced studies in a variety of areas through the prestigious Hospital of Special Surgery in New York.
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| 7 | Chemical and functional genomic approaches to stem cell biology and regenerative medicine / edited by Sheng Ding | Wiley | 2008 | QU325 C5165 2008 | Basic |
Scientists believe that stem cells have the potential to repair specific tissues and to grow organs, revolutionizing the treatment of cardiovascular disease, neurodegenerative disease, musculoskeletal disease, diabetes, and cancer. A core reference for researchers, Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine consolidates the latest information on functional genomics and chemical biology approaches that are used to study and control the fate of stem cells. It discusses new technologies and their recent applications in various areas of stem cell biology, covering: The use of both embryonic and adult stem cells, A vast array of technologies, including: genome-wide expression analysis, functional genomic profiling with arrayed cDNA and RNAi expression libraries, informatics, chemical genomics, mass spectrometry, and proteomics, The applications of advanced technologies in various areas of stem cell biology, encompassing: self-renewal, differentiation, and reprogramming of different types of embryonic and adult stem cells, as well as regeneration in model organisms, Technological tools for studying the biology of stem cells, With chapters contributed by leading authorities.
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| 8 | Dry eye : a practical guide to ocular surface disorders and stem cell surgery / edited by Amar Agarwal | SLACK | 2006 | WW208 D7984 2006 | Basic |
Dry eye and ocular surface disorders are complex conditions with multiple modes of treatment. Navigate your way through the perplexities with Dry Eye: A Practical Guide to Ocular Surface Disorders. Dr. Amar Agarwal has arranged a comprehensive and easy-to-read text focusing on this hot topic. With expert contributors from around the world, Dry Eye explains all there is to know about dry eye disorders and management.
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| 9 | Essentials of stem cell biology / edited by Brigid Hogan ... [et al.] ; editor-in-chief, Robert Lanza | Academic | 2009 | QU325 H236 2009 e-book | Basic |
First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.
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| 10 | Hematopoietic stem cell biology / Motonari Kondo, editor | Humana | 2010 | WH380 H486915 2010 | Basic |
This book is written by experts in the field of hematopoietic stem cell biology and lymphocyte development in order to overview recent advances in the field. Prospective isolation of various progenitors and stem cells enables us to understand self-renewal mechanisms of stem cells as well as regulation of hematopoiesis. Furthermore, the importance of extrinsic factors has been emphasized recently. This volume concisely describes our current understanding of normal hemato/lymphopoiesis as well as abnormal hematopoiesis, which may lead to leukemia.
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| 11 | Human embryonic stem cells : the practical handbook / editors, Stephen Sullivan, Chad A. Cowan and Kevin Eggan | John Wiley & Sons | 2007 | QU328 H918 2007 | Basic |
With this valuable practical guide, three members of the Harvard Stem Cell Institute have compiled and edited the definite handbook for the exciting new field of human embryonic stem cell research. The editors have gathered protocols from scientists with extensive reputation and expertise, describing and comparing currently used techniques for the culture of human stem cells and discussing the strengths and weaknesses of the different approaches. The Practical Handbook contains the first centralised collection of methods used in human embryonic stem cell biology. The book covers the derivation of human stem cell lines, the obtaining of cells from human stem cell banks, the culturing and characterisation of the cells, and the differentiation of the cells in vitro and in vivo. Lastly, almost all of these protocols can also be used for analyzing and manipulating induced pluripotency iPS stem cells. This allows an even greater number of opportunities for those interested in purusing work in pluripotent stem cells, disease modelling, and other aspects of basic regenerative medicine research.
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| 12 | Imaging and spectroscopic analysis of living cells : imaging live cells in health and disease / edited by P. Michael Conn | Academic | 2012 | QU25 C719 v.506 2012 | Basic |
This volume of Methods in Enzymology is the third of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. The second of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike.
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| 13 | In-vitro fertilization / Kay Elder, Brian Dale ; with contributions from Yves Ménézo, Joyce Harper and John Huntriss | Cambridge University | 2011 | WQ208 E375 2011 | Basic |
This fully updated new edition of a successful and popular practical guide is an indispensable account of modern in-vitro fertilization practice. Initial chapters cover theoretical aspects of gametogenesis and embryo development at the cellular and molecular level, while the latter half of the book describes the requisites for a successful IVF laboratory and the basic technologies in ART. Advanced techniques, including pre-implantation genetic diagnosis, vitrification and stem-cell technology, are comprehensively covered, providing up-to-date analyses of these groundbreaking technologies. This edition includes: New practical techniques, including preservation of fertility for cancer patients, stem-cell biology/technology, vitrification and in-vitro maturation. A refresher' study review of fundamental principles of cell and molecular biology. The latest information available from animal and human research in reproductive biology Packed with a wealth of practical and scientific detail, this is a must for all IVF practitioners.
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| 14 | Mesenchymal stem cells for the heart : from bench to bedside / Jian'an Wang, Xiaojie Xie | Zhejiang Univercity | 2009 | QU325 M5778 2009 e-book | Basic |
Stem cell research has the potential to affect the lives of millions of people around the world. This research is now regularly front-page news, and realizing the promise of mesenchymal stem cells for yielding new medical therapies will require us to grapple with more than just scientific uncertainties. "Mesenchymal Stem Cells for the Heart - From Bench to Bedside" presents the cytobiological characteristics of mesenchymal stem cells from the isolation, culture, transmembrane ion currents, migration and differentiation in vitro to the repairing of injured myocardium and tissue reconstruction in vivo, including the results of basic research and the real possibility for treatments and ultimately for cures for cardiac diseases for which adequate therapies do not exist. The book is intended for clinical stem cell researchers in cardiovasology, hematology, cytobiology, molecular biology, cell and tissue engineering, and other related fields.
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| 15 | Methods in bioengineering : stem cell bioengineering / Biju Parekkadan, Martin L. Yarmush, editors | Artech House | 2009 | QU325 S8235 2009 | Basic |
Written and edited by recognized experts in the field, the new Artech House Methods in Bioengineering book series offers detailed guidance on authoritative methods for addressing specific bioengineering challenges. Offering a highly practical presentation of each topic, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. This cutting-edge volume is focused on methods to derive, manipulate, target, and/or prepare stem cells for clinical use. The book helps you master powerful stem cell bioengineering methods, enabling them to rigorously test hypotheses and compare their results to "gold standards".
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| 16 | Pancreatic stem cells / Juan Domínguez-Bendala | Humana | 2009 | WI800 D671p 2009 e-book | Basic |
From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.
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| 17 | Perinatal stem cells / edited by Curtis L. Cetrulo, Kyle J. Cetrulo, Curtis L. Cetrulo Jr | John Wiley & Sons | 2009 | QU325 P445 2009 | Basic |
Normally discarded as medical waste, perinatal stem cells are an incredible source of stem cells and are gaining phenomenal research attention for their potential to become a more powerful alternative to the controversial embryonic stem cells. In response to this growing field, Perinatal Stem Cells provides a thorough tutorial on the current state of the art in perinatal stem cells. Perinatal Stem Cells is a bountiful source for researchers, graduate students, cell biologists, gene therapists, obstetricians and gynecologists, and professionals engaged in regenerative medicine and developmental biology.
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| 18 | Primary and stem cells : gene transfer technologies and applications / edited by Uma Lakshmipathy, Bhaskar Thyagarajan | John Wiley and Sons | 2012 | QU325 P9522 2012 | Basic |
This book describes basic cell engineering methods, emphasizing stem cell applications, and use of the genetically modified stem cells in cell therapy and drug discovery. Together, the chapters introduce and offer insights on new techniques for engineering of stem cells and the delivery of transgenes into stem cells via various viral and non-viral systems. The book offers a guide to the types of manipulations currently available to create genetically engineered stem cells that suit any investigator's purpose, whether it's basic science investigation, creation of disease models and screens, or cells for therapeutic applications.
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| 19 | Stem cell and gene-based therapy : frontiers in regenerative medicine / [edited by] Alexander Battler and Jonathan Leor | Springer | 2006 | QU325 S8234 2006 | Basic |
Regenerative medicine - stem cell and gene-based therapy - provides a new clinical approach for restoring function of damaged organs and tissues. There has been incredible progress in experimental strategies for tissue regeneration, particularly in cell transplantation and stem cell research. These have led to potential treatment options for many otherwise fatal conditions, including end-stage organ failure. Cell therapy and tissue engineering of viable grafts could therefore provide prospective new solutions to the serious problems of organ donor shortage.
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| 20 | Stem cell controversy : debating the issues / edited by Michael Ruse and Christopher A. Pynes | Prometheus | 2006 | QU325 S8236 2006 | Basic |
Recent advances in medical research have shown that embryonic stem cells can be used to treat some of the most debilitating diseases, notably Parkinson's Disease, spinal injuries, and nerve-cell damage. Yet the troubling ethical downside of this promising technology is that up till now the main source of stem cells has been tissue taken from aborted fetuses. This practice has raised sharp criticisms from opponents of abortion who charge that science is attempting to capitalize on a procedure that to them is abhorrent. Proponents of stem-cell research argue that scientists are making legitimate use of already-aborted fetuses and it is unfair to deprive those suffering from serious diseases and injuries of a potentially revolutionary therapy. The issue has become so important that in August 2001, President Bush addressed the nation on new developments in stem cell research and the ethical dilemmas this technology poses.
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| 21 | Stem cell culture / edited by Jennie P. Mather | Academic | 2008 | W1 M566c v.86 2008 | Basic |
Interest in the therapeutic value of embryonic, fetal and adult stem cell types is rapidly expanding throughout the scientific community. The first half of this century should see an explosion of therapeutic applications of stem cells which will grow from the cells and techniques described in this book. Stem Cell Culture provides a comprehensive resource for researchers in the fields of embryonic, fetal and adult stem cell biology to find methods for the purification, culture, and differentiation of these cell types, with the main emphasis on the maintenance of the stem cell phenotype in vitro. This volume will be the first to broadly cover multiple types of stem cell culture from different ages, organs and species. Chapters focus on the practical do's and don'ts of isolating and culturing these cell types, and use illustrative data or diagrams that allow the reader to confidently apply techniques and make this a standard reference.
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| 22 | Stem cell-based tissue repair / edited by Raphael Goradetsky and Richard Schäfer | Royal Society of Chemistry | 2011 | QU325 S824 2011 | Basic |
The need for customized stem cell therapies for specific conditions will be a major issue in the coming decades. This unique book by experts in the field reviews the subject as it stands today. Its coverage includes: basic and applied stem cell research and history; sources of adult stem cells; a comparison of difficulties in derivation, and the applications of embryonic and adult stem cells. Specific topics dealt with include advantages and problems associated with stem cell / matrix interactions and stem cell differentiation, difficulties using stem cells for clinical application, stem cell based tissue engineering - myth or reality, stem cells and immunity, natural biological matrices versus synthetic (biocompatibility and integration), stem cell delivery, labeling, imaging and tracking, bioreactors: 2D and 3D cell culturing for in-vitro studies and for stem cell implantation, ethical and safety issues and Good Manufacturing Practice (GMP).
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| 23 | Stem cells : scientific facts and fiction / written and edited by Christine Mummery ... [et al.] | Academic | 2011 | QU325 S7485 2011 | Basic |
In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues of which everyone presumed were unable to regenerate in adults; these include particularly the heart and the brain. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson, diabetes and spinal cord lesions based on the use of stem cells and entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. As is often the case in science, many early claims turned out to be different from those expected. Embryonic stem cell therapies have not moved rapidly into clinical practice. Adult stem cells certainly have given certain degrees of success but not nearly to the extent that advocates would have wished for. Some claims of early successes in adult stem cell therapies have not been sustained in double-blinded, randomized clinical trials. Some claims are now close to routine therapy. Some of the claims not supported by evidence have nevertheless reached private clinical practice so that "stem cell tourism" is beginning to reach exaggerated proportions.
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| 24 | Stem cells in regenerative medicine / edited by Julie Audet and William L. Stanford | Humana | 2009 | QU25 S824 2009 e-book | Basic |
As regenerative medicine involves replacing diseased cells, tissues or organs, or repairing tissues in vivo, the manipulation of stem cells underlie its goals. In Stem Cells in Regenerative Medicine: Methods and Prools, leading experts in the field provide an updated representation of the landscape of stem cell-based therapies in a wide spectrum of tissue systems and ontogenic stages, from the isolation and culture of stem cells to their actual use in vivo. Written in the highly successful Methods in Molecular Biology™ series format, these chapters include brief introductions to the topic, lists of the necessary materials and reagents, readily reproducible, step-by-step laboratory prools, and tips for troubleshooting and avoiding known pitfalls. Comprehensive and easy-to-use, Stem Cells in Regenerative Medicine: Methods and Prools is certain to contribute greatly to the definition of standardized procedures for the manipulation of somatic and embryonic stem cells in research and clinical applications.
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| 25 | Telomeres and telomerase in ageing, disease, and cancer : molecular mechanisms of adult stem cell ageing / K. Lenhard Rudolph, editor | Springer | 2008 | QU470 T2774 2008 | Basic |
The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and health span in the growing populations of the elderly. Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction. A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations.
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| 26 | Trends in stem cell biology and technology / Hossein Baharvand, editor | Humana | 2009 | QU325 T7942 2009 e-book | Basic |
The study of stem cell research has recently gained the attention from a growing, multidisciplinary community of scientists; this exponential growth of interest is driven by the hope of discovering cures of several diseases through transplantation medicine. Trends in Stem Cell Biology and Technology aptly serves this developing community as it reveals new aspects of stem cell research by specifically covering studies focused on spermatogonial stem cells, uniparental embryonic stem cell lines, the generation of gametes from stem cells, reprogramming germ cells to stem cells, nuclear and somatic cell genetic reprogramming, tissue engineering and mechanotrasduction of stem cells and finally the development of stem cell technologies for the treatment of deafness, heart disease, corneal injury and diabetes. With contributions by leading scientists and renowned scholars, Trends in Stem Cell Biology and Technology offers a wide audience cutting edge information at a crucial time in this ever expanding field.
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| 27 | 海神效應 / 安.帕爾森(Ann B. Parson)著 ; 楊玉齡譯 | 張老師 | 2006 | 364 4614 | Basic |
有些生物學家相信，幹細胞帶給我們最偉大的財產，是它的治療價值。另外一些生物學家說，它們最大的好處，在於能告訴我們生命的奇蹟，一個小小的細胞，如何具有生長茁壯的能耐，以及所有大自然的奧祕。還有一些生物學家則將幹細胞視為不朽的細胞，未來將能幫助人類無限地延長壽命，使得老化成為異常的現象。幹細胞是生命的原料，靜候細胞信息的誘導，變形成為會跳動的心肌細胞，會製造胰島素的胰臟細胞，或是會傳送信息的中央神經系統細胞。如果調控得當，它們便能轉變成我們所需的細胞類型，那麼，幹細胞很可能成為醫治帕金森氏症、糖尿病、心臟病、自體免疫疾病、不孕症的新法寶，難怪引發臍帶血等生技產品新風潮！但是，幹細胞到底是怎麼回事？幹細胞真能許諾細胞醫療光明的未來？安．帕爾森的《海神效應－幹細胞與其對醫學的承諾》帶我們回到歷史，看科學家們如何漸漸意識到生物體內存在著這些獨特、但又不易察覺的細胞，如何讓我們更為接近生命不朽之祕。
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