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腦與腸的對談
推薦老師：生理學研究所余佳慧老師

        腦腸軸(Brain-gutaxis)一詞起源於臨床症狀的觀察，即精神壓力會導致腸道的功能性失調。廣義的解釋是腦和腸之間藉由神經傳導與免疫、內分泌機制進行雙向溝通。臨床上常見腦腸軸失調的疾病包括「腸躁症」、「功能性消化不良症候群」、「胃食道逆流疾病」、「週期性嘔吐綜合症」等。其中「腸躁症」是現代社會壓力下常見的疾病，其發病率相當高，約占腸胃科門診人數的10-40%。「腸躁症」病徵是腹部的疼痛或絞痛，合併有腸道功能的改變，包括脹氣、腹瀉或便秘。其原因不明，且無生物標的，利用內視鏡也觀察不到腸道病變，因此過去「腸躁症」被視作精神疾病。最新研究得知「腸躁症」病人對精神壓力的抗性較低，較易出現恐慌和憂鬱症狀，且腸道有低程度發炎、共生菌增生和上皮屏障失常的現象。

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編號 書名 / 作者 出版社 出版年 索書號 適用等級 摘要
1 Achieving the mind-body-spirit connection : a stress management workbook / Brian Luke Seaward Jones and Bartlett 2005 WB880 S442 2005 Basic bookpic The association between stress and disease is well documented, from the common cold to cancer. Stress also distorts decision making, disrupts emotional thought-processing, and compromises the health of the human spirit. Good stress management is nothing more than common sense, but in a fast-paced, fragmented society, good sense is anything but common. Achieving the Mind-Body-Spirit Connection serves as a wonderful reminder of what we know at the deepest level of our being: Optimal health requires the integration, balance, and harmony of mind, body, spirit, and emotions. Drawing upon the disciplines of psychology, physiology, sociology, theology, anthropology, mythology, and quantum physics, Brian Luke Seaward blends the proven tenets of ageless wisdom with a score of practical ideas, suggestions, and exercises to help you achieve harmony between mind, body, spirit, and emotions. From comic relief and hatha yoga to guided mental imagery and music therapy, this workbook contains more than 70 exercises that serve to integrate mind, body, and spirit as one dynamic force that can withstand the pressures of whatever stress may come your way.
2 Bioactive peptides / edited by John Howl, Sarah Jones CRC 2009 QU68 B6133 2009 e-book Advanced bookpic The study and diverse applications of bioactive peptides traverse many sub-disciplines within chemistry, biology, physics, and medicine. Answering a long-standing need, Bioactive Peptides focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. Moving peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics, it presents the overall contributions that peptide science has made to molecular, cellular, and whole organism biology, while also discussing future targets and therapeutic applications. With mounting worldwide interest in their therapeutic potential, bioactive peptides-including the identification of new species, the synthesis of structural analogues, and diverse applications in biology and medicine-will likely remain at the forefront of scientific endeavor for many decades. Providing even casual readers with a broad flavor of the nature and applications of peptides, this volume attracts and excites tomorrow's researchers who are charged with further developing and implementing the findings presented herein.
3 Cell/tissue injury and cytoprotection/organoprotection in the gastrointestinal tract : mechanisms, prevention and treatment / volume editors, Ludmila P. Filaretova, Koji Takeuchi Karger 2012 W1 F928 v.30 2012 Advanced bookpic In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
4 Clinician's guide to acid/peptic disorders and motility disorders of the gastrointestinal tract / [edited by] Henry P. Parkman, Robert S. Fisher SLACK 2006 WI195 C6409 2006 Advanced bookpic Acid/peptic disorders and motility disorders of the gastrointestinal tract are among the most common disorders affecting the general population. The Clinician's Guide to Acid/Peptic and Motility Disorders of the Gastrointestinal Tract is a practical guide that offers access to the advances made in recent years in acute treatment and maintenance therapy. Drs. Henry Parkman and Robert Fisher have compiled a unique reference for the management of patients with these gastrointestinal disorders. Comprehensive and user-friendly, the topics covered in the treatment of acid/peptic disorders and motility disorders range from daily medication and on-demand regimens to gastric electrical stimulators. The Clinician's Guide to Acid/Peptic and Motility Disorders of the Gastrointestinal Tract will highlight clinical advances made in the care of patients, including a focus on symptoms, causes, evaluation, and treatment.
5 Cognitive-behavioral therapy for anxiety disorders : mastering clinical challenges / Gillian Butler, Melanie Fennell, Ann Hackmann Guilford 2008 WM172 B985c 2008 Advanced bookpic Helping therapists bring about enduring change when treating clients with any anxiety disorder, this invaluable book combines expert guidance, in-depth exploration, and innovative clinical strategies. The authors draw on extensive experience and research to provide a framework for constructing lucid formulations of complex cases. They identify obstacles that frequently arise during the early, middle, and later stages of treatment and present a wide range of practical solutions. The volume demonstrates clear-cut yet flexible ways to enhance client engagement, foster metacognitive awareness, facilitate emotional processing, address low self-esteem and fear of uncertainty, and much more, including reproducible handouts and forms.
6 Constipation : etiology, evaluation and management / [edited by] Steven D. Wexner, Graeme S. Duthie Springer 2006 WI409 C7583 2006 Advanced bookpic The only book to deal specifically with constipation for specialists has been updated to include all the new advances since the first edition (1995). These advances include biofeedback, surgery for constipation, sacral nerve stimulation, the use of laparoscopy for rectal prolapse, treament and our understanding of some of the psychological problems of these patients. Innovations also include Professor Norman Williams’ Malone Procedure and the newer pharmacologic treatments such as nitric oxide and botulinum toxin injections.
7 Curbside consultation in IBD : 49 clinical questions / edited by David T. Rubin, Sonia Friedman, Francis A. Farraye SLACK 2009 WI420 C975 2009 Advanced bookpic Are you looking for concise, practical answers to questions that are often left unanswered by traditional IBD references? Are you seeking brief, evidence-based advice for complicated cases or complications? Curbside Consultation in IBD: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a “curbside consultation” between colleagues. Curbside Consultation in IBD: 49 Clinical Questions provides information that high-volume clinicians will appreciate, and yet is basic enough for residents. Gastroenterologists, fellows and residents in training, surgical attendings, and surgical residents will benefit from the user-friendly and casual format and the expert advice contained within.
8 Curbside consultation in IBS : 49 clinical questions / [edited by] Brian E. Lacy SLACK 2011 WI520 C9751 2011 Advanced bookpic Are you looking for concise, practical answers to questions that are often left unanswered by traditional IBS references that are not designed for gastroenterologists? Are you seeking brief, evidence-based advice for complicated cases or patients with complications that need management? Curbside Consultation in IBS: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a “curbside consultation” between colleagues. Dr. Brian E. Lacy has designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with IBS. The unique Q&A format provides quick access to current information related to IBS with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate the treatment of IBS patients.
9 Early detection and prevention in colorectal cancer / edited by Karen E. Kim SLACK 2009 WI529 E12 2009 Advanced bookpic Colorectal cancer is the third most common malignancy in the United States and the third leading cause of cancer mortality in both men and women. As gastroenterologists and primary care physicians are faced with patients with colorectal cancer, the future road to decreasing these numbers begins with increased knowledge and awareness of the effects that biology, genetics, environment, and lifestyle have on the disease. In Early Detection and Prevention of Colorectal Cancer, Dr. Karen Kim and her esteemed contributors take a comprehensive look into the world of colorectal cancer and the ways that today’s physician can positively impact the patient’s outcome.
10 Emerging issues in inflammatory bowel disease / edited by A. Fraser ... [et al.] Springer 2006 WI420 F191e 2006 Basic bookpic This book contains the proceedings of Falk Symposium 151 on ‘Emerging Issues in Inflammatory Bowel Diseases’, held in Sydney, Australia, March 2006, the first symposium of its kind both in the southern hemisphere and in the Asia-Pacific region. This interdisciplinary symposium brings together basic science and clinical applications. It presents the first major text where "East meets West" in IBD.
11 Evidence-based gastroenterology and hepatology / edited by John W.D. McDonald ... [et al.] Wiley-Blackwell 2010 WI140 E927 2010 Advanced bookpic The only evidence-based resource combining gastroenterology and hepatology, this major textbook critically appraises the evidence for diagnosis, screening, and treatment of gastrointestinal and hepatic diseases, and provides clear recommendations for management. A unique feature is the grading of both the evidence (randomized controlled trials, systematic reviews, or lower quality trials) and the treatment recommendations. This structure provides the reader with valuable guidance on implementation.
12 Gastrointestinal and liver disease nutrition desk reference / edited by Gerard E. Mullin, Laura E. Matarese, Melissa Palmer CRC 2012 WI140 G258 2012 e-book Basic bookpic While the gastrointestinal tract ingests, digests, and absorbs nutrients, the liver transforms nutrients, synthesizes plasma proteins, and detoxifies bacteria and toxins absorbed from the gut. It is therefore not surprising that gastrointestinal and hepatic diseases have a major impact on the nutritional state of the individual. Integrating nutrition and the gastrointestinal system, the Gastrointestinal and Liver Disease Nutrition Desk Reference brings together experts in the field of nutrition, gastroenterology, and hepatology to offer dietary, nutritional, and natural therapies for gastrointestinal and hepatic ailments in order to improve overall health.
13 Gastrointestinal pathology : an atlas and text / Cecilia M. Fenoglio-Preiser ... [et al.] Lippincott Williams & Wilkins 2008 WI140 G2589 2008 Advanced bookpic Completely updated for its Third Edition, this full-color text/atlas is a comprehensive reference on gastrointestinal pathology in adults and pediatric patients. The book integrates pathologic analyses of specimens with anatomic, clinical, radiologic, pathophysiologic, and microbiologic information to give readers a clear understanding of each disease process. The outstanding selection of over 3,000 illustrations includes gross and microscopic photographs, electron micrographs, radiographs, and line drawings. Chapters cover non-neoplastic and neoplastic lesions of each anatomic section and disorders affecting multiple anatomic sites. This edition includes many new illustrations, significant updates on mesenchymal tumors, motility disorders, and inflammatory bowel disease, and new information on molecular biologic changes in various disorders.
14 Handbook of prebiotics / edited by Glenn R. Gibson, Marcel Roberfroid CRC 2008 QU145.5 H2359 2008 e-book Basic bookpic Gathering contributions from leading experts in a range of disciplines, Handbook of Prebiotics- Discusses the biomechanics of prebiotics and their interactions with gut microbiota, Discusses the concept, definition and criteria for classification as prebiotics, Highlights the current evidence and arguments for and against prebiotic intake, Describes prebiotic effects on immune status, serum lipid concentrations, mineral bioavailability, and satiety modulation, Considers the health implications of prebiotic intake such as reduced incidence of gastroenteritis and chronic pathogenic gut disorders including intestinal cancers and inflammatory bowel diseases, Examines the varying effects of prebiotics in different populations and age groups such as infants and the elderly, as well as livestock and pets, Includes potential applications and safety implications for prebiotic use in food products, Spans several disciplines to include sound research science and well-balanced views on the potential of prebiotics for promoting good health.
15 Immune mechanisms in inflammatory bowel disease / edited by Richard S. Blumberg, Markus F. Neurath Springer 2006 WI420 I33 2006 Advanced bookpic Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.
16 Inflammation and cancer : methods and protocols / edited by Serguei V. Kozlov Humana 2009 QZ25 I43 2009 v.1-2 Advanced bookpic According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Prools, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 1, Experimental Models and Practical Approaches provides an overview of a spectrum of techniques developed to analyze the outcomes of inflammation-mediated carcinogenesis on the tissue, cellular, and molecular levels while highlighting several diagnostic aspects, such as biomarker discovery and molecular signatures evaluation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory prools, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls.
17 Inflammation and gastrointestinal cancers / Janusz A.Z. Jankowski, editor Springer 2011 W1 R243 v.185 2011 Advanced bookpic Inflammation in gastrointestinal mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it has fundamental clinical consequences, the principal of which is premalignant metaplasia throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for GI cancer. This book discusses all aspects of the relation between inflammation and GI cancer, from the basic science through to the translational science which is helping in the optimization of clinical management strategies. Among the topics considered are the impact of inherited syndromes; the roles of acid reflux, H. pylori, inflammatory bowel disease, and primary sclerosing cholangitis; screening strategies; targeted drug therapies; genetics; and the use of endoscopic methods. The authors are the best in their field, and this book is designed for the enthusiastic student as well as the professional in GI science and medicine.
18 Integrative gastroenterology / edited by Gerard E. Mullin Oxford University 2011 WI140 I605 2011 Advanced bookpic Digestive complaints have become increasingly common. Recent statistics show that gastrointestinal complaints account for nearly a third of all visits to primary care doctors and that nearly one in six Americans suffer from digestive disease. In this volume, an international panel of leading experts provides a wealth of information for health care practitioners and consumers on the rationale, methods, modalities, and efficacy of integrative solutions for gastrointestinal disorders. Coverage includes a diverse range of treatment methods, such as meditation, massage, yoga, supplements, special diets, energy medicine, homeopathy, and acupuncture, as well as a special section devoted to mind-body medicine in digestive health and disease. In discussing unconventional treatments, the authors address many of the controversies that surround the remedies.
19 Mental health and disasters / edited by Yuval Neria, Sandro Galea, Fran H. Norris Cambridge University 2009 WM31 M5435 2009 Basic bookpic Since the attacks of September 11, 2001, disaster preparedness and response has developed into a discrete subspecialty in medicine, and the paramount health care initiative of the U.S. Government. The mental health component of disaster response is a serious subject of study, as trauma is associated with a substantial and long-lasting psychologic burden, both on an individual and community level. The psychopathologies associated with disaster are also quite broad, varying from several different types of post-traumatic stress and anxiety disorders to acute variations of grief-associated depression. This book is the definitive reference on mental health and disasters, focused on the assessment and treatment of the full spectrum of psychopathologies associated with many different types of individual disasters. The logistics for utilizing pre-existing community-based mental health services, as well as the development of new programs, are covered in depth. Case studies and perspectives for improving care, incorporating lessons from Hurricane Katrina and 9/11, are included in detail.
20 Pediatric inflammatory bowel disease : perspective and consequences / volume editors, John A. Walker-Smith, Emanuel Lebenthal, David Branski Karger 2009 WI420 P3717 2009 Advanced bookpic Chronic inflammatory bowel disease (IBD) encompasses Crohn's disease, ulcerative colitis and indeterminate colitis. The distinct phenotype in pediatric and adolescent patients and the difference from adult IBD make early-onset IBD a unique subgroup requiring specific therapeutic considerations. In this book, leading experts from the USA, Europe and Israel present new data on the genetics, epidemiology, pathology and pathogenesis of pediatric IBD. Imaging and endoscopy in the diagnosis of IBD are also discussed. Extensive coverage is given to disease management, i.e. pharmacological, nutritional and surgical approaches, with special emphasis on growth failure and delayed puberty. The important topic of transition from pediatric to adult medical care is highlighted and a clinical and developmental timeline is proposed. Offering practical information on IBD in infants, toddlers, children, adolescents and young adults, this book is essential reading for gastroenterologists, in particular pediatric gastroenterologists and trainees, as well as general pediatricians and nutritionists.
21 Pediatric inflammatory bowel disease / edited by Petar Mamula, Jonathan E. Markowitz, Robert N. Baldassano Springer 2008 WI420 P371 2008 Advanced bookpic This textbook focuses on the pediatric aspects of Inflammatory Bowel Disease (IBD). It covers diagnostic approaches, special nutrition, growth, and bone density, as well as psychosocial considerations that are specific to the young and may thus not exist in adults. Chapters discuss the full range of topics from IBD genetics right through to nutritional and growth aspects and condition management. The book features many visual aids as well as endoscopy and surgery images.
22 Post-traumatic and acute stress disorders / Matthew J. Friedman Jones & Bartlett 2012 WM172.5 F9075p 2012 Advanced bookpic Post-traumatic and Acute Stress Disorder, Fifth Edition is a concise, up-to-date presentation of the latest scientific information and clinical challenges regarding posttraumatic stress disorder (PTSD) as well as acute reactions to stressful events. Written for non-PTSD specialists including practitioners in general psychiatry, primary care practitioners and graduate students, Post Traumatic & Acute Stress Disorder, Fifth Edition explicitly addresses diagnostic, including differential diagnostic, and assessment issues. This newest edition now includes current examples of PTSD in military personnel deployed to Iraq and Afghanistan.
23 Post-traumatic stress disorder / [edited by] Dan J. Stein, Matthew J. Friedman, and Carlos Blanco Wiley-Blackwell 2011 WM172.5 P8571 2011 Advanced bookpic Despite the growing interest in the role of psychological trauma in the genesis of psychiatric disorders, few volumes have addressed these issues from a multidisciplinary and international perspective. Given the complexity of resilience and post-traumatic disorder, and given ongoing trauma and violence in many parts of the world, it is crucial to apply such perspectives to review existing knowledge in the field and provide directions for future research. This book has a broad scope. A key focus is PTSD, because of its clinical and health importance, its obvious link with trauma, and its interest for many clinicians and researchers. However, the book also examines resilience and a range of mental health consequences of trauma, because it has become increasingly clear that not all individuals react to trauma in the same way. It is important for mental health professionals to be aware of the broad range of potential responses to trauma, as well as of relevant evidence-based treatments.
24 Principles and practice of stress management / edited by Paul M. Lehrer, Robert L. Woolfolk, Wesley E. Sime ; foreword by David H. Barlow Guilford 2007 WM172.4 P957 2007 Basic bookpic Structured for optimal use as a clinical reference and text, this comprehensive work reviews effective stress management techniques and their applications for treating psychological problems and enhancing physical health and performance. Leading experts present in-depth descriptions of progressive relaxation, hypnosis, biofeedback, meditation, cognitive methods, and other therapies. Tightly edited chapters examine each method's theoretical and empirical underpinnings and provide step-by-step guidelines for assessment and implementation, illustrated with detailed case examples. The volume also explains basic mechanisms of stress and relaxation and offers research-based guidance for improving treatment outcomes.
25 Psychological knowledge in court : PTSD, pain, and TBI / Gerald Young, Andrew W. Kane, Keith Nicholson, editors Springer 2006 W740 P97352 2006 Advanced bookpic PTSD, pain syndromes, traumatic brain injury: these three areas are common features of personal injury cases, often forming the cornerstone of expert testimony. Yet their complex interplay in an individual can make evaluation—and explaining the results in court—extremely difficult. Psychological Knowledge in Court focuses on this triad separately and in combination, creating a unique guide to forensic evaluations that fulfills both legal and clinical standards. Its meticulous review of the literature identifies and provides clear guidelines for addressing core issues in causality, chronicity, and assessment.
26 Stress consequences : mental, neuropsychological and socioeconomic / editor in chief George Fink Academic 2010 WM172.4 S9158 2010 Advanced bookpic Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that focuses on the physical and psychological consequences of stress for individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing’s Syndrome: Addison’s Disease) and the adverse impact of stress on human physical and mental health. Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is also placed on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries.
27 Stress hormones and post traumatic stress disorder : basic studies and clinical perspectives / edited by E. Ronald de Kloet and Melly S. Oitzl, Eric Vermetten Elsevier 2008 W1 P943br v.167 2008 Advanced bookpic Post-traumatic stress disorder (PTSD) arises from the experience of severe stressors and trauma. The disorder is characterized by recurrent recall of intrusive memories to the event, nightmares with insomnia, emotional numbing, hyperarousal, which are all long-lasting and relatively resistant to therapy. The focus of this book is on the question of how stress hormones are involved in PTSD. Recent evidence suggests that a dysregulation in stress hormones promotes the precipitation of PTSD and that correction of these hormones may ameliorate the disorder. This book combines state-of-the-art basic research on stress hormones from gene to behaviour with clinical research demonstrating the progress in understanding via imaging techniques, genetics, vulnerable phenotypes and co-morbidity with other disorders and physical illness.
28 Textbook of anxiety disorders / edited by Dan J. Stein, Eric Hollander, Barbara O. Rothbaum American Psychiatric 2010 WM172 T356 2010 Advanced bookpic This important new resource offers both clinicians and researchers a single-volume resource that covers not only advances in clinical interventions but also the latest advances in theoretical knowledge. Following a comprehensive overview of anxiety disorders, the book provides detailed coverage of seven specific DSM-IV-TR diagnoses: generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), mixed anxiety-depression, panic disorder, social anxiety disorder, specific phobias, and posttraumatic stress disorder (PTSD). Each section covers the latest thinking on symptomatology and pathogenesis, then provides evidence-based clinical recommendations for pharmacotherapy and psychotherapy.