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病毒感染與頭頸癌
推薦老師：耳鼻喉科婁培人老師

        儘管近年來有許多的研究嘗試去了解癌症與其產生的原因，慢性感染在致癌過程中所扮演的角色卻一直被忽略。根據世界衛生組織的報告，在已開發國家的所有癌症中與感染症有關的癌症佔8%，而開發中國家的所有癌症中與感染症有關的癌症則佔23%，較為熟知的包括肝癌(與肝炎病毒有關)、子宮頸癌(與人類乳突瘤病毒有關)、胃癌(與幽門桿菌感染有關)，以及鼻咽癌(與EB病毒感染有關)。近年來的研究發現，口咽癌(例如扁桃癌、舌根癌等)與人類乳突瘤病毒的感染有非常密切的關係。在歐美口咽癌的腫瘤組織中，有70%左右的腫瘤可以找到人類乳突瘤病毒感染的跡象，尤其是發生在女性，不抽菸的口咽癌患者，人類乳突瘤病毒感染的機率更高，而這類病人治療之後的預後通常也較好。研究感染與癌症的關係除了可以幫助我們了解這些癌症特殊的致病機制外，這些感染源(病毒、細菌)更能提供我們針對相關癌症特殊的篩檢、治療，甚至預防的方法。

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編號 書名 / 作者 出版社 出版年 索書號 適用等級 摘要
1 Basic virology / Edward K. Wagner ... [et al.] Blackwell  2008 WC500 W132b 2008  Basic bookpic This third edition of a text for introductory and intermediate undergraduate students offers a full-color art program, with a wealth of detailed explanatory diagrams and computer-generated images. It contains a new chapter on HIV and the lentiviruses, as well as a new section on new approaches and problems in viruses, with chapters on the molecular tools used to study viruses, viral pathogenesis at the molecular level, viral genomics and bioinformatics, and viruses and the future. The glossary has been revised, and there are new case studies which provide a clinical perspective of the viral diseases. Other pedagogical features include chapter outlines, review questions, problems, and web links. Wagner was professor of molecular biology and biochemistry at the University of California-Irvine.
2 Cancer control / edited by J. Mark Elwood, Simon B. Sutcliffe Oxford University 2010 QZ200 C21512 2010 Basic bookpic Cancer control is the term applied to the development of integrated population-based approaches to reduce the incidence and mortality from cancer and to minimize its impact on affected individuals and on the community. It covers a spectrum of prevention, early diagnosis, optimal treatment, and supportive and palliative care. It emphasizes the application of new knowledge gained through research to achieve current best practice. Cancer control has become a political priority in many countries in recent years, with the evolution of both national and regional cancer control strategic plans. The integrated nature of cancer control, involving a wide spectrum of health care professionals, researchers, and health managers and planners, is reflected in this multi-disciplinary text, which is the first in this rapidly developing field.
3 Clinical and diagnostic virology / Goura Kudesia, Tim Wreghitt Cambridge University 2009 WC39 C6403 2009 Advanced bookpic The book comprehensively covers, in simple language, viral illness, diagnostic methods, and other important issues with viral infections in the healthcare environment. The information is uniquely provided in concise charts, diagrams, and algorithms....The understanding of diagnostic techniques and when to apply them is this book's strength....This book finally provides a necessary guide to vast and confusing array of diagnostic tests.
4 Diagnostic surgical pathology of the head and neck / [edited by] Douglas R. Gnepp Thieme 2009 WE705 D536 2009  e-book Advanced bookpic This resource is the authoritative guide to problematic areas of the head and neck for the surgical pathologist. With particular emphasis placed on diagnostic problems and differential diagnosis in addition to coverage of more common diagnostically straightforward lesions, you’ll get the most complete diagnostic picture possible. The updated second edition features new coverage and a more user-friendly layout. Expert Consult functionality allows you to access the entire contents of the book online, from any internet connection.
5 DNA tumor viruses / Blossom Damania, James M. Pipas, editors Springer 2009 QW166 D6295 2009 e-book Basic bookpic The DNA tumor viruses are central to many branches of molecular and cellular biology. This very diverse group of viruses attack common cellular pathways, which makes them powerful tools for understanding how multiple complex pathways are integrated. Additionally, the unique mechanisms employed by each viral system to alter cellular functions serve as powerful molecular probes for the identification of new targets and pathways. The scientific impact of the DNA tumor viruses extends far beyond their etiologic role in human cancers, or their contributions to our basic understanding of the cellular pathways that drive tumorigenesis. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions.
6 Dx/Rx. Human papilloma virus / Don S. Dizon, Ashley R. Stuckey, Michael L. Krychman  Jones & Bartlett 2012 QZ39 D9939 2012 Basic bookpic Dx/Rx: Human Papilloma Virus is a handy, pocket-sized manual that details precise, up-to-date information for diagnosis and treatment of Human Papilloma Virus (HPV). Throughout the book, tables and figures summarize important clinical data and current professional society recommendations, while salient references direct readers to additional information. Dx/Rx: Human Papilloma Virus dispels public myths surrounding HPV and features current, quick, and concise information for instant access on the ward or in the clinic.
7 Epidemiology, pathogenesis, and prevention of head and neck cancer / edited by Andrew F. Olshan Springer 2010 WE707 E641 2010 Basic bookpic The purpose of this book is to provide a current perspective on the epidemiology head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established risk factors, suggested association with a virus, and potential genetic susceptibility determinants. These tumors offer a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction.
8 Essential otolaryngology : head & neck surgery / edited by K.J. Lee McGraw-Hill 2008 WV18.2 E78 2008  Basic bookpic The ninth edition of this medical student's guide to head and neck surgery has been expanded to include new information on cysts and tumors of the jaw, TNM classifications in otolaryngology and malignant melanoma. Editor Lee (otolaryngology, Yale U. School of Medicine) collects diagnostic algorithms and case studies for conditions such as sinusitis, sensory disorders, cancer and sleep disorders so that readers can prepare for general reviews, board certifications and re-certifications. Several new international contributors have been added since the last edition to provide a more global approach to treatment options.
9 Fundamentals of molecular virology / Nicholas H. Acheson Wiley 2007 QW160 A177f 2007 Basic bookpic Designed for students learning about viruses for the first time(t the undergraduate or graduate level), Fundamentals of Molecular Virology is presented in a style which relates to today's students and professors. The text approaches learning about virology by presenting a set of chapters each of which covers a specific virus family, using one or two well-studied viruses as examples. Each chapter is designed to tell a story about the virus under discussion, and to portray the personality of that virus. The text incorporates lessons from classic and contemporary concepts providing a well-rounded presentation on the subject of virology.
10 Head and neck cancer / edited by Wayne M. Koch Elsevier 2010 WE707 E12 2010 Advanced bookpic Recent research on early diagnosis and treatment of head and neck cancer is collected here, in 13 chapters by contributors from The Johns Hopkins Hospital and other medical institutions on the East Coast. Some topics include molecular gene alterations as early-detection markers, molecular proteomics in early detection, strategies for oral cancer detection, and chemoprevention. Other subjects include early treatment of the larynx, sentinel lymph node biopsy for oral cancer, and the solitary thyroid nodule. The book features a two-color layout with b&w and color images, photos, and illustrations. A companion web site is available. Koch is affiliated with The Johns Hopkins Hospital.
11 Head and neck cancer : an evidence-based team approach / [edited by] Eric M. Genden, Mark A. Varvares Thieme 2008 WE707 H431726 2008 Advanced bookpic Each topic includes input by a surgeon, a medical oncologist, and a radiation oncologist, case studies, clinical and surgical photographs, line drawings and step-by-step instructions, making this a synthesis of the collective wisdom. Topics covered include carcinoma of the oral cavity, oropharynx, hypopharynx, larynx, thyroid, salivary glands, nasal cavity, paranasal sinus, nasopharynx, and skin of the head (including face and neck). The topics include material on diagnosis, treatment planning and implementation, and reconstruction techniques. Particularly interesting is an article of management of carcinoma of an unknown primary site and another containing advice on the surveillance of the patient. The result is a very effective self-study guide and professional reference that would also work as a classroom text.
12 HPV and other infectious agents in cancer : opportunities for prevention and public health / Hans Krueger ... [et al.] Oxford University 2010 Basic bookpic Experts in oncology, clinical research, and public health review recent research on disease mechanisms, population-based risk assessment, and policy in the field of cancer prevention, focusing on infectious agents strongly associated with cancer. Although the main thrust of each chapter is a standard literature review of high-quality review articles and individual research studies, the book goes beyond literature review to discuss the science and emerging clinical implications of individual infectious agents in cancer, offerng insight on current and future methods of prevention. Six chapters are devoted to the transmission, carcinogenesis, diagnosis, and prevention of human papilloma virus (HPV); the remaining five chapters are devoted to five other infectious agents in cancer: hepatitis viruses, the bacterium H. Pylori, Epstein-Barr virus, human herpes virus type 8, and human T-cell lymphotrophic virus. This structure allows HPV to serve as a paradigm for both the biological understanding and the prevention responses of each of the other infectious agents covered.
13 Inflammation and cancer : methods and protocols / edited by Serguei V. Kozlov Humana 2009 Basic bookpic According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Prools, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 1, Experimental Models and Practical Approaches provides an overview of a spectrum of techniques developed to analyze the outcomes of inflammation-mediated carcinogenesis on the tissue, cellular, and molecular levels while highlighting several diagnostic aspects, such as biomarker discovery and molecular signatures evaluation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory prools, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls.
14 Jatin Shah's head and neck surgery and oncology / Jatin P. Shah, Snehal G. Patel, Bhuvanesh Singh Elsevier 2012 Advanced bookpic Head and Neck Surgery and Oncology, by Drs. Jatin P. Shah Snehal G. Patel, and Bhuvanesh Singh, offers you authoritative, multidisciplinary guidance on the latest diagnostic and multidisciplinary therapeutic approaches for head and neck cancer. With this medical reference book, you’ll have all the help you need to offer your patients the best possible prognoses and to optimally preserve and restore form and function. This comprehensive text will assist in improved survival and preserving and restoring form and function with the surgical treatment of tumors.
15 Multidisciplinary management of head and neck cancer / [edited by] Robert I. Haddad Demos Medical 2011 Advanced bookpic For clinicians, Haddad (head and neck oncology, Harvard Medical School) compiles 11 chapters that emphasize a multidisciplinary approach to the diagnosis, treatment, and outcomes for patients with head and neck cancer. Focusing on treatment strategies like chemotherapy, concurrent chemoradiotherapy, and sequential chemoradiotherapy, an international group of oncologists and surgeons also discuss biologic and targeted therapies, radiation therapy, the role of human papillomavirus (HPV) infections in oropharynx cancer, nuclear imaging, advances in nasopharyngeal and thyroid cancers, new surgical techniques including robotic and minimally invasive surgery, and the evaluation and treatment of dysphagia and aspiration.
16 Principles of molecular virology / Alan J. Cann Elsevier 2012 Basic bookpic The fifth edition of the highly successful Principles of Molecular Virology takes on a molecular approach to the explanation of virology, presenting basic in a clear, concise and student-friendly manner. This fully updated undergraduate text explores and explains the fundamental aspects of virology, including structure of virus particles and genome, replication, gene expression, infection, pathogenesis and subviral agents. A website with self-assessment questions and other resources aids in student understanding.
17 Structural virology / edited by Mavis Agbandje-McKenna and Robert McKenna Royal Society of Chemistry 2011 e-book Advanced bookpic Molecular biologists apply the principles and techniques of structural biology to viruses, both to provide useful information and to demonstrate the utility of the approach. Their topics include producing and purifying viruses for structural studies, the X-ray crystallography of virus capsids, the evolution of viral capsid structures, mechanisms of icosahedral virus assembly, attachment and entry, developing anti-HIV drugs, and viral vectors for gene delivery. Distributed in the US by Ingram Publisher Services.
18 Vaccines / Stanley A. Plotkin, Walter A. Orenstein and Paul A. Offit Saunders 2008 Basic bookpic This esteemed volume, first published in 1988 (and the previous, fifth edition was published in 2008), carries forward the mission of providing a comprehensive reference to the immeasurably valuable tool of vaccination. Plotkin (emeritus, pediatrics, U. of Pennsylvania) is one of the original editors; he's joined for this edition by Orenstein (medicine, pediatrics, and global health, Emory U.) and Offit (infectious diseases, The Children's Hospital of Philadelphia)--all of whom have other affiliations as well. They point out in the preface that only two vaccines have been added since the fifth edition, but great strides have been made in the application of previously developed vaccines and in the exploitation of genetic engineering to make new vaccines; supply and financing has evolved; and partial success has been achieved against HIV and malaria. It's notable that Microsoft's Bill Gates supplies the foreword (his foundation has put money behind vaccination efforts worldwide).
19 Viral oncology : basic science and clinical applications / edited by Kamel Khalili, Kuan-Teh Jeang Wiley-Blackwell 2010 e-book Basic bookpic Khalili (neuroscience, Temple U.) and Jeang (molecular virology, National Institutes of Health) bring together 21 chapters in this first self-contained and comprehensive book of scientific and clinical information on viruses linked to human cancers, for oncologists, clinicians and scientists working in biomedical areas, medical students, and pharmaceutical scientists and developers. Researchers working in oncology, cell and molecular biology, genetic engineering and biotechnology, virology and microbiology, neuroscience, and other medical fields in the US, Europe, and Asia cover viruses associated with brain tumors, colorectal cancer, prostate cancer, mesothelioma, hepatitis B and C-associated cancer, HIV-associated malignancy and lymphoma, and Kaposi's sarcoma; human papillomavirus and human T-cell leukemia virus type 1-associated cancers; the biology and epidemiology of human herpes virus-8; and Epstein-Barr virus infection. Pathogenesis, drug development, employment of viral vectors for vaccine and gene therapy, prevention, and treatment are discussed.
20 鼻咽癌 / 高黎,徐国镇主编 北京大學醫學出版社 2007 Basic bookpic 中國的華南地區是全世界鼻咽癌的高發地區，由於鼻咽癌的解剖學和病理學特點決定了其主要治療手段是放射治療。該書總結了幾代人臨床診療的經驗，結合國內外鼻咽癌研究的新進展，全面闡述了鼻咽癌的診斷、放射治療的基礎、各種放射治療的方法、放療前中後及各種損傷的臨床處理．鼻咽癌的綜合治療和特殊類型鼻咽癌的治療。是一部實用性很強的專業書籍。對相關專科醫生的臨床治療規範及其放療技術的瞭解提供參考和幫助。